The histamine H4 receptor, belonging to the family of G-protein coupled receptors, is an increasingly attractive drug target.It plays an indispensable role in many cellular pathways, and numerous H4R ligands are being CENTAURY studied for the treatment of several inflammatory, allergic, and autoimmune disorders, including pulmonary fibrosis.Activat
Background/Objectives: Dual-modality probes, combining positron emission tomography (PET) with fluorescence imaging (FI) capabilities in a single molecule, are of high relevance for the accurate staging and guided resection of tumours.We herein present a pair of candidates targeting the cholecystokinin-2 receptor (CCK2R), namely [68Ga]Ga-CyTMG and
Objective: This study aimed to evaluate the safety, efficacy, and feasibility of the rituximab, fotemustine, pemetrexed, and dexamethasone (R-FPD) regimen followed by whole-brain radiotherapy (WBRT) for patients with primary central nervous system lymphoma (PCNSL).Methods: A prospective, single-center phase II clinical trial was conducted.Patients